This invention discloses compounds that alter PPAR activity. The invention
also discloses pharmaceutically acceptable salts of the compounds,
pharmaceutically acceptable compositions comprising the compounds or
their salts, and methods of using them as therapeutic agents for treating
or preventing disipidemia, hypercholesteremia, obesity, eating disorders,
hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia
and diabetes in a mammal as well as methods of supressing appetite and
modulating leptin levels in a mammal. The present invention also
discloses methods for making the disclosed compounds.
