Polypeptides are expressed by the pituitary-tumor-transforming-gene
(PTTG), formerly known as pituitary-tumor-specific-gene (PTSG), and nucleic acids
encode them. Examples are the human and rat PTTG proteins. The nucleic acids may
be applied to the production of a recombinant protein, and to the detection of
the presence of PTTG genes in different species. The nucleic acids may be operatively
linked to a vector, optionally provided with control and expression sequences and/or
being carried by a host cell. The nucleic acids may also be delivered to a mammal
to compensate for the absence, or a defective expression, of endogenous protein.
The nucleic acids, proteins, and antibodies are also employed in disgnostic assays,
as well as, for example, in the production of anti-PTTG antibodies (protein), therapeutic
compositions and other applications of the proteins and antibodies. Various kits
utilize nucleic acids, polypeptides, and/or antibodies. A transgenic non-human
mammal expresses PTTG.
