The invention relates generally to naphthyridine derivatives of the formula
##STR1##
wherein one of U, X, Y and Z is nitrogen and the others are CR, where
R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine
derivatives and pharmaceutical compositions containing such derivatives. Methods
of the invention comprise administration of a naphthyridine derivative of the invention
for the treatment of diabetes and related disorders.
