There are provided a method for selection of a substance which is capable of
controlling activation of prorenin where an adjusting ability of the activation
of prorenin by protein-protein interaction in a profragment region of prorenin
as indicator is used; a prorenin activation controlling substance having a function
of controlling the activation of prorenin based on protein-protein interaction
by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor
and arterial thickening suppressor containing the prorenin activation controlling
substance as an effective ingredient.
