There are provided 2-aminopurine derivatives represented by the following general
formula (1):
##STR1##
where R represents any species selected from the group consisting of hydrogen
and acyl groups, X represents any species selected from the group consisting of
phosphoramidite and oligonucleotides, Y represents any species selected from the
group consisting of dimethyltrityl groups and oligonucleotides, and Z1,
Z2, Z3, Z4 and Z5 are the same or different
and represent any species selected from the group consisting of hydrogen and hydroxyl,
amino, lower alkyl, alkoxy, carboxyl and sulfonic acid groups, provided that Z1,
Z2, Z3, Z4 and Z5 are not all hydrogen,
as well as gene expression-regulating compositions characterized by comprising
the derivatives. By introducing the 2-aminopurine derivatives into oligonucleotides
it is possible to achieve crosslinking reaction with high reactivity for target
nucleic acids and notably high base sequence specificity.
