Compounds which are alpha-1A/B adrenoceptor antagonists and which are
represented by Formula I: 1
wherein Q is a monocyclic or bicyclic optionally-substituted heterocyclic
ring as defined herein; Z is --C(.dbd.O)-- or --S(.dbd.O).sub.2--; R and
R' are lower alkyl; R.sup.5 is halogen, cyano, hydroxy, --R.sup.6, or
--OR.sup.6; and R.sup.6 is alkyl, substituted alkyl, aryl, substituted
aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted
cycloalkyl, heterocyclo, or substituted heterocyclo; and
pharmaceutically-acceptable salts, hydrates, prodrugs, and isomers
thereof.
