The invention relates to the production and use of retroviral vectors for cell
specific gene transfer, specially to a production method of retroviral vectors
containing capsid particles of murine leukemia virus (MLV) and envelope proteins
of human immunodeficiency vises (HIV) or simian immunodeficiency viruses (SIV).
Said vectors can be used for gene transfer in selected cell types, specially in
CD4-positive mammal cells.