An anti-CEA monoclonal antibody, designated 806.077, of murine origin is useful
for the diagnosis and therapy of cancer. The antibody complementarity determining
regions have the following sequences: heavy chain CDR1 DBYMH CDR2 WIDPENGDTE YAPKFRG,
CDR3 LIYAGYLAMD Y; and light chain CDR1 SASSSVTYMH, CDR2 STSNLAS, CDR3 QQRSTYPLT.
The antibody optionally is humanized and can be in the form of a conjugate with
either an enzyme, such as carboxypeptidase, or a co-stimulatory molecule such as
the extracellular domain of human B7.1.
