The subject invention pertains to novel microdialysis probes having highly advantageous
structural features, particularly for clinical applications. A microdialysis probe
of the subject invention can be introduced into a biological tissue using insertion
means such that the insertion means can the be completely dissociated from the
biological tissue and the microdialysis probe. The microdialysis probes of the
subject invention can further include guiding means composed of imageable material
that may be used to guide the microdialysis probes to a target tissue using the
appropriate sensing equipment. A further aspect of the subject invention relates
to methods of using novel microdialysis probes to assess the presence or absence
of a substance within biological tissue. The subject invention further relates
to methods of using novel microdialysis probes to deliver a substance within biological tissue.
