A controlled release dosage form for sertraline has a core comprising a sertraline-containing
composition and a water-swellable composition wherein the water-swellable composition
is in a separate region within the core. A coating around the core is water-permeable,
water-insoluble, and has at least one delivery port therethrough. In one embodiment,
the dosage form releases sertraline to the use environment at an average rate of
6 to 10 wt % per hour from the second to the twenth hour after introduction to
a use environment and less than about 25 wt % for the first two hours and at least
70 wt % by the twelfth hour, where the percentages correspond to the mass of drug
released from the tablet divided by the total mass of drug originally present in
the tablet. In another embodiment, the dosage form releases less than about 25
wt % of sertraline to the use environment by the second hour after introduction
of the dosage form to the use environment, and delivers at least 25 wt % from the
eighth to the twenty-fourth hour.
