The present invention relates to a compound of the formula [1]
##STR1##
wherein R2 is lower alkyl optionally substituted by hydroxy, amino
and the like, ring B is phenyl, thienyl and the like, E is a single bond, O,
S and the like, ring G is aryl, heterocyclic group and the like,
R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen
atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of
2 to 5, each R5 may be the same or different, m is 0 or an integer of
1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing
compound [1] as an active ingredient. The compound [1] shows, due
to nociceptin antagonistic action, analgesic effect against sharp pain such as
postoperative pain and the like. The present invention also relates to the use
of certain amide derivative inclusive of compound [1] as a nociceptin antagonist
or analgesic.
