Quinazoline derivatives as medicaments

The invention is directed to methods to inhibit TGF- and/or p38- kinase using compounds of the formula ##STR1##

or the pharmaceutically acceptable salts thereof

• wherein R³ is a noninterfering substituent;
• each Z is CR² or N, wherein no more than two Z positions in ring A are N, and

  wherein two adjacent Z positions in ring A cannot be N;

• each R² is independently a noninterfering substituent;
• L is a linker;
• n is 0 or 1; and
• Ar is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.