It is to provide a process for synthesizing an intended fluorine-containing compound
having a geminal difluoro structure with a high yield, by subjecting a carbonyl
compound which is readily available to a two-stage reaction.
A compound (1) such as ethyl 4-oxocyclohexanecarboxylate is reacted with a compound
of the formula X-Z or a compound of the formula Z2O (wherein Z is a
monovalent group which gives a leaving group of the structure OZ, and X
is a chlorine atom, a bromine atom or an iodine atom) such as phosphorus pentachloride,
and then a fluorinating agent which generates fluorine anions such as HF is acted
thereon to obtain a fluorine-containing compound (2) such as ethyl 4,4-difluorocyclohexanecarboxylate
##STR1##
