The invention relates to a multiparticulate modified release composition that
in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate
modified release composition comprises an immediate release component and a modified
release component; the immediate release component comprising a first population
of active ingredient containing particles and the modified release component comprising
a second population of active ingredient containing particles coated with a controlled
release coating; wherein the combination of the immediate release and modified
release components in operation deliver the active ingredient in a pulsed or a
bimodal manner. The invention also relates to a solid oral dosage form containing
such a multiparticulate modified release composition. The plasma profile achieved
by the multiparticulate modified release composition is advantageous in reducing
patient tolerance to the active ingredient and in increasing patient compliance
by reducing dosage frequency.
