Novel mammalian secretory polypeptides, polynucleotides encoding the
polypeptides (called Zsig9), and related compositions and methods
including antibodies and anti-idiotypic antibodies. Overexpression of
these proteins is indicative of the presence of cancer. Antibodies and
anti-sense nucleotides can be used therapeutically to treat the disease.
Furthermore, antibodies to Zsig9 and nucleotide primers and probes can be
used to diagnose the presence of tumors.