The present invention provides the receptors for Mob-5 (IL-24). One of the Mob-5
receptors comprises IL-22R1 and IL-20R2. Another Mob-5 receptor comprises IL-20R1
and IL-22R2. The invention also provides methods of inhibiting the Mob-5 receptor
as well as methods of detecting cancer by detecting the presence of the Mob-5 receptor.