The invention provides isolated nucleic acid molecules, designated TANGO
228 nucleic acid molecules, which encode secreted proteins with homology
to the rat MCA-32 protein, isolated nucleic acid molecules, designated
TANGO 240 nucleic acid molecules, which encode secreted proteins with
homology to the Mycobacterium tuberculosis hypothetical protein Rv0712,
and isolated nucleic acid molecules, designated TANGO 243 nucleic acid
molecules, which encode proteins with homology to human PLAP
(phospholipase A2-activating protein).
The invention also provides antisense nucleic acid molecules, expression
vectors containing the nucleic acid molecules of the invention, host
cells into which the expression vectors have been introduced, and
non-human transgenic animals in which a nucleic acid molecule of the
invention has been introduced or disrupted. The invention still further
provides isolated polypeptides, fusion polypeptides, antigenic peptides
and antibodies. Diagnostic, screening and therapeutic methods utilizing
compositions of the invention are also provided.
