The invention provides diagnostic methods and kits including oligo and/or
polynucleotides or derivatives, including as well antibodies determining
whether a human subject is at risk of getting adverse drug reaction after
statin therapy or whether the human subject is a high or low responder or
a good a or bad metabolizer of statins. The invention provides further
diagnostic methods and kits including antibodies determining whether a
human subject is at risk for a cardiovascular disease. Still further the
invention provides polymorphic sequences and other genes. The present
invention further relates to isolated polynucleotides encoding a
phenotype associated (PA) gene polypeptide useful in methods to identify
therapeutic agents and useful for preparation of a medicament to treat
cardiovascular disease or influence drug response, the polynucleotide is
selected from the group comprising: SEQ ID 1-80 with allelic variation as
indicated in the sequences section contained in a functional surrounding
like full length cDNA for PA gene polypeptide and with or without the PA
gene promoter sequence.
