The present invention relates, at least in part, to methods of modulating
apoptosis in cells, comprising contacting the cell with a compound that
modulates the expression, post-translational modification, or activity of
Ian4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60. The subject
methods can be used to treat a variety of different disorders, for
example, autoimmune disease and neoplasia. The invention also pertains to
methods for identifying compounds that modulates the activity of Ian-4,
leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60.
