The present invention is related to substituted methylene amide
derivatives of formula (I) and use thereof for the treatment and/or
prevention of metabolic disorders mediated by insulin resistance or
pyperglycemia, comprising diabetes type I and/or II, inadequate glucose
tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia,
hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In
particular, the present invention is related to the use of substituted
methylene amide derivatives of formula (I) to modulate, notably to
inhibit the activity of PTPs. Also the present invention relates to a
method of treating diabetes type II, obesity and to regulate the appetite
of mammals. The present invention is furthermore related to novel
substituted methylene amide derivatives and method of preparation
thereof. Formula (I). 1
