Lactam-containing compounds and derivatives thereof as factor Xa inhibitors

   
   

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P.sub.4-P-M-M.sub.4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

 
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