The present application describes lactam-containing compounds and
derivatives thereof of Formula I:
P.sub.4-P-M-M.sub.4 I
or pharmaceutically acceptable salt forms thereof, wherein ring P, if
present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7
membered carbocycle or heterocycle. Compounds of the present invention
are useful as inhibitors of trypsin-like serine proteases, specifically
factor Xa.