Peptido and peptidomimetic compounds of the formula:
##STR1##
wherein the formula variables are as defined in the disclosure, advantageously
inhibit or block the biological activity of the picornaviral 3C protease. These
compounds, as well as pharmaceutical compositions containing these compounds, are
useful for treating patients or hosts infected with one or more picornaviruses,
such as RVP. Intermediates and synthetic methods for preparing such compounds are
also provided.
