The invention relates to isolated nucleic acid molecules encoding MutS homologues
(MSHs). Such MSH proteins are involved in DNA mismatch-repair processes in organisms.
The invention provides isolated nucleic acid molecules comprising MSH2 nucleotide
sequences which encode MSH2 proteins and MSH2 nucleotide sequences which encode
dominant-negative MSH2 variants. Such MSH2 nucleotide sequences find use in altering
mismatch repair, mutation rates and recombination frequencies in both eukaryotic
and prokaryotic organisms. The invention also provides isolated nucleic acid molecules
comprising MSH2 promoter nucleotide sequences. Such MSH2 promoter nucleotide sequences
find use in regulating the expression of genes of interest in plants. Additionally
provided are isolated proteins, transformed host cells, and transformed plants,
tissues, cells and seeds thereof.
