A lipid preparation including a glycerophospholipid or salt, conjugate and
derivatives thereof, particularly phosphatidylserine (PS),
phosphatidylcholine (PC), phosphatidylethanolamine (PE),
phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic
acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups,
particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups
such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is
covalently bound to said glycerophospholipid. The preparation possesses
an improved bioactivity, and is useful in the treatment of various
cognitive and mental conditions and disorders and for maintenance of
normal functions of brain-related systems and processes.