The present invention is methods and compositions for reducing and preventing
the excess accumulation of extracellular matrix in a tissue and/or organ or at
a wound site using a combination of agents that inhibit TGF, or using agents
that inhibit TGF in combination with agents that degrade excess accumulated
extracellular matrix. The compositions and methods of the invention are used to
treat conditions such as fibrotic diseases and scarring that result from excess
accumulation of extracellular matrix, impairing tissue or organ function or skin
appearance in a subject.
