The present invention is directed to a method of reducing intraocular
pressure. The method comprises administering to a subject a
pharmaceutical composition comprising an effective amount of a nucleoside
5'-pyrophosphate pyranoside or analogue, which is defined by general
Formula I. The method of the present invention is useful in the treatment
or prevention of ocular hypertension, such as found in glaucoma,
including primary and secondary glaucoma. The method can be used alone to
reduce intraocular pressure. The method can also be used in conjunction
with another therapeutic agent or adjunctive therapy commonly used to
treat glaucoma to enhance the therapeutic effect of reducing the
intraocular pressure. The present invention also provides a novel
composition comprising a nucleoside 5'-pyrophosphate pyranoside or
analogue.
