A polymerase inhibitor has first moiety coupled to a second moiety via an optional
linker in which the first moiety binds to an initiation nucleotide binding site
of a polymerase and forms at least two hydrogen bonds with an RNA template strand
that is associated with the polymerase, and in which the second moiety comprised
a compound that binds to a site proximal to the nucleotide binding site of the
polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.
