The present invention provides a novel compound having a superior calcium antagonism,
in particular, a neuron-selective calcium antagonism. Namely, it provides a compound
represented by the following formula, a salt thereof or a hydrate of them.
##STR1##
In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic
ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine,
a piperidine and the like; the ring B indicates an optionally substituted C3-14
on hydrocarbon ring etc.; E indicates a single bond, a group represented by the
formula CO, etc.; X indicates a single bond, an oxygen atom etc.;
R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.;
and D1, D2, W1 and W2 are the same
as or different from each other and each represents a single bond or an optionally
substituted C1-6 alkylene chain.
