A method is disclosed for providing extended duration treatment or
prevention of pain, inflammation and inflammation-related disorders in a
subject in need of such extended duration treatment or prevention by
administering to the subject a Cox-2 selective inhibitor having certain
added substituent groups. Also disclosed is a method for extending the
duration of the plasma half-life of diaryl-substituted Cox-2 selective
inhibitors by substituting halogen, haloalkyl, haloalkoxy, alkyl,
nitrile, cyano or alkoxy groups at certain positions on the
diaryl-substituted rings of the inhibitor molecule. A novel composition
comprising such extended duration Cox-2 selective inhibitors is also
disclosed.
