Systems, bone screws, and methods for delivering a treatment agent into or
near a bone, such as a vertebra are provided. The system include a hollow
prosthetic vertebral body having one or more fenestrations and a liner
containing a treatment agent disposed within the hollow prosthetic
vertebral body. The liner is designed to provide for the controlled
release of the treatment agent. Also provided are refillable cannulated
bone screws having a resealable seal for delivering a treatment agent to
a bone.
