Novel anti-IL-23p40 specific human Ig derived proteins, including, without
limitation, antibodies, fusion proteins, and mimetibodies, isolated
nucleic acids that encode the anti-IL-23p40 Ig derived proteins, vectors,
host cells, transgenic animals or plants, and methods of making and using
thereof, are useful for therapeutic compositions, methods and devices.
Preferably, the anti-IL-23p40 specific human Ig derived proteins do not
bind the p40 subunit of IL-12 and, thus, do not neutralize IL-12-related
activity.