This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as
protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed
herein are of Formula 1
##STR1##
and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof,
wherein R1, R2, R3, R4, X, Y, and Z
are defined herein. The invention further relates to pharmaceutical compositions
and dosage forms comprising compounds of Formula 1 and to methods of their use
for the treatment and/or prevention of diseases such as, but not limited to, cancer.
