The present invention features rifamycin analogs that can be used as
therapeutics for treating or preventing a variety of microbial
infections. In one form, the analogs are acetylated at the 25-position,
as is rifamycin. In another form, the analogs are deacetylated at the
25-position. In yet other forms, benzoxazinorifamycin,
benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized
at various positions of the benzene ring, including 3'-hydroxy analogs,
and/or various fused ring systems with the benzene ring at the 4',5' or
5',6' positions.
