A method of treating Parkinson's disease in humans is disclosed, wherein
glial cell-line derive neurotrophic factor (GDNF) is chronically
administered directly to one or both putamen of a human in need of
treatment thereof via convection-enhanced infusion using at least one
implantable pump and at least one catheter. In one aspect of the present
invention the GDNF is infused directly into one or both putamen through
one or more indwelling intraparenchymal mutltiport brain catheters
connected to one or moreimplantable pumps wherein the flow rate is
pulsed.
