Benzopyranone Compounds having the following structure: 1
wherein R.sub.1, R.sub.2, X, Y and n are as defined herein, are disclosed.
The Benzopyranone Compounds are useful for treating or preventing a
bone-resorbing disease, a neoplastic disease, arthritis, a disease
exacerbated by the presence of estrogen or a disease improved by the
presence of estrogen, comprising administering an effective amount of a
Benzopyranone Compound to a patient in need of the treating or
preventing; activating the function of estrogen receptor ("ER") in a bone
cell; inhibiting the function of ER in a cancer cell; inhibiting the
expression of interleukin-6 ("IL-6") in a cell; and inhibiting the growth
of a neoplastic cell, comprising contacting the cell with an effective
amount of a Benzopyranone Compound.
