Methods of preparing, and compositions comprising, derivatives of (-;)-venlafaxine
are disclosed. Also disclosed are methods of treating and preventing diseases and
disorders including, but not limited to, affective disorders such as depression,
bipolar and manic disorders, attention deficit disorder, attention deficit disorder
with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders,
obesity and weight gain, incontinence, dementia and related disorders.