The present application is directed to stabilized HIV envelope glycoprotein trimers.
The trimers are stabilized by introducing trimeric motifs, preferably the GCN4
coiled coil or the fibritin trimeric domain at certain sites, for example in the
gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers
can be used to generate an immunogenic reaction. The trimers can also be used in
assays to screen for molecules that interact with them-and to identify molecules
that interact with specific sites.
