Systems and methods are described for, among other things, detecting tissue
injury and for evaluating the integrity of an anatomic structure. A system may
include a first sensor disposable through a first space on a first side of the
anatomic structure, a second sensor disposed in a second space on a second side
of the anatomic structure, and a processor coupled to the first sensor and to the
second sensor, the processor including a meter, the meter responsive to a communication
between the first sensor and the second sensor, wherein an invasion of the anatomic
structure by the first sensor alters the communication between the first sensor
and the second sensor.