Disclosed are compounds of the formula: 1
wherein the formula variables are as defined herein. The compounds of this
invention are non-peptide, reversible inhibitors of type 2 methionine
aminopeptidase. Also disclosed is the use of such compounds in treating
conditions mediated by angiogenesis, such as cancer, haemangioma,
proliferative retinopathy, rheumatoid arthritis, atherosclerotic
neovascularization, psoriasis, ocular neovascularization and obesity.
