Adenosine A3 receptor agonists

Disclosed are novel adenosine A₃ receptor agonists of Formula I: ##STR1##

• wherein:
• R is hydrogen or lower alkyl;
• R¹ is optionally substituted lower alkoxy or optionally substituted cycloalkyloxy;
• R² is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted trialkylsilyl; and
• R³ is hydroxymethyl or R⁴R⁵NC(Q)-;
• in which R⁴ and R⁵ are hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl.