The following description refers to a process for the impregnation of cross-linked
polymers with an active ingredient. The process is based on the used of compressed
fluids, in particular CO2, with antisolvent effect, and involves the
steps of impregnating the polymer with an active ingredient solution, adding a
compressed fluid until precipitation of the active ingredient caused by the compressed
fluid antisolvent effect, removing the solvent and the compressed fluid. The process
allows to obtain accelerated release pharmaceutical formulations that, compared
with the formulations already known, contain larger quantities of amorphous or
nanocrystalline active ingredient.
