The invention provides compositions comprising a plurality of yeast cells, wherein
said plurality of yeast cells are characterized by their ability to normalize the
level of serum glutamate-pyruvate Transaminase (GPT), or reduce serum HBsAg levels
in a subject, said ability resulting from their having been cultured in the presence
of an alternating electric field having a specific frequency and a specific field
strength. Also provided are methods of making and using these compositions.