The present invention relates to cyclic urea derivatives, their synthesis, and
their use as v integrinreceptor antagonists. More particularly, the compounds
of the present invention are antagonists of the integrin receptors v3
and/or v5 and are useful for inhibiting bone resorption, treating
and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy,
macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, tumor
growth and metastasis.
