The invention relates to pharmaceutical compositions and methods of
treating inflammatory-related diseases associated with pro-inflammatory
cytokine expression and/or reduced expression of anti-inflammatory
cytokines. The method typically comprises administration of one or more
compounds selected from isoindigo, indigo, indirubin, or derivatives
thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical
composition comprises one or more compounds selected from isoindigo,
indigo, indirubin, or derivatives thereof, an anti-inflammatory agent,
and a pharmaceutically acceptable carrier.