A 5-membered cyclic compound of the formula:
##STR1##
wherein X is oxygen or sulfur, R1 is hydrogen, substituted or
unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted
alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond,
substituted or unsubstituted alkylene, -CO(CH2)n-, etc.,
the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted
or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene,
etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted
or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof,
these compound being able to inhibit infiltration of leukocytes such as eosinophils
and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
