The present invention provides methods, reagents, and kits for diagnosing and
treating cancer in a mammal, e.g., a human. This invention is based upon the discovery
that G2A, GPR4, GPR65, and OGR1 are overexpressed and/or amplified in cancer. Methods
to detect cancer or a propensity to develop cancer, to monitor the efficacy of
a cancer treatment, and to treat cancer, by inhibiting the expression and/or activity
of G2A, GPR4, GPR65, and OGR1 in a cancer cell are included.
