The invention provides a system which comprises a medical device that delivers
a combination of therapies. These therapies include the administration of radiation,
biologically active materials, cryotherapy, and thermotherapy. The present invention
is also directed to a method of treating body lumen surfaces using the system of
the invention. A system is provided for delivering a biologically active material
to a surface of a body lumen being exposed to a radioactive source. In one aspect,
the system comprises an implantable medical device which has two opposing ends,
each having a surface, and a middle portion. The two opposing ends comprise a biologically
active material and the middle portion of the medical device is substantially free
of any biologically active material. In another aspect, the system delivers a genetic
material to a surface of a body lumen which is exposed to a radioactive source.
Another system is provided for treating a surface of a body lumen in which the
system comprises an implantable medical device which comprises a biologically active
material and a device for applying a therapy source to the parts of the body lumen
surface that are in contact with the opposing ends of the medical device. The therapy
source may be a cryotherapy source or a thermotherapy source.
