A method and compound for the purification of proteins including the attachment
of a non-peptidic, small compound which simulates the affinity of Protein A for
immumoglobulins to a support matrix. Once attached on the support matrix, the resulting
monochloro-triazine derivative is reacted with an excess of an amino compound at
a higher temperature to achieve high levels of substitution. The resulting support
matrix with ligand is useful in the affinity separations of antibodies. Further,
a mercapto heterocyclic system ligand may be attached to the super matrix and useful
in affinity separations of antibodies.
