Provided are in vivo screening methods to detect and identify substances
that affect neuronal viability, and/or prevent neurodegeneration, and/or
confer neuroprotective effects The screening methods utilize recombinant
C. elegans expressing a detectable marker in neuronal sub-groups and the
use of neurotoxins specific to specific neuronal cells. Also provided are
methods for identifying modulators of neurotransmitter transporters such
as the dopamine transporter. Therefore, the invention provides methods
for identifying substances that can be used in the prevention and therapy
of neurodegenerative diseases.
