Compositions and methods are disclosed which facilitate purification
of oligomers and other compounds. The disclosed compositions are silyl compositions
that can be directly coupled, or coupled through a linking group, to a compound
of interest, preferably to an oligomer at the end of oligomer synthesis. The silicon
atom includes between one and three sidechains that function as capture tags. In
one embodiment, the capture tags are lipophilic, which allows a derivatized oligomer
to be separated from failure sequences by reverse phase chromatography. In another
embodiment, the capture tags are compounds with a known affinity for other compounds,
which other compounds are preferably associated with a solid support to allow chromatographic
separation. Examples include haptens, antibodies, and ligands. Biotin, which can
bind to or interact with a streptavidin-bound solid support, is a preferred capture
tag of this type.
